Polynucleotides are fast becoming one of the most scientifically validated treatments in regenerative aesthetics, a step beyond temporary hydration or volumising injectables. Supported by robust clinical evidence and guided by expert medical practice, they represent a biologically intelligent way to restore the skin’s integrity from within.
At Aesthetic Health, Dr Julia Sevi and her team have long championed a diagnostic-led, regenerative approach that treats the root causes of ageing. This article explores what the science says about polynucleotides, how they work on a cellular level, and why ongoing maintenance sessions are crucial for lasting, cumulative rejuvenation.
What the Science Says – Clinical Data Supporting Polynucleotides
Proven Mechanisms of Action
Polynucleotides are purified DNA fragments derived from natural sources. Their power lies in biostimulation, triggering the skin’s own repair systems rather than adding artificial volume.
- Fibroblast activation: Studies confirm that polynucleotides stimulate fibroblasts, the cells responsible for collagen and elastin production.
- Collagen and hyaluronic acid synthesis: Clinical research published in MDPI 2023 and SpringerLink 2024 shows measurable increases in dermal density and hydration through enhanced extracellular matrix (ECM) activity.
- Anti-inflammatory regulation: Polynucleotides help reduce oxidative stress and inflammatory signalling, supporting long-term skin health.
These biological mechanisms make them a cornerstone of regenerative aesthetics, offering a holistic way to restore elasticity, tone, and radiance.
Evidence from Clinical Studies
Independent trials continue to demonstrate their efficacy across multiple skin concerns, from fine lines and texture to overall dermal thickness.
- A 2024 PubMed review found consistent improvements in elasticity and hydration within 4-12 weeks of treatment.
- Comparative studies show enhanced outcomes when polynucleotides are combined with microneedling, energy-based devices, or other regenerative injectables such as calcium hydroxyapatite and PRP.
- Dermatologists’ consensus protocols typically recommend a three-session induction course, spaced three to four weeks apart, followed by maintenance sessions two or three times per year to sustain fibroblast stimulation.
This accumulating body of data supports what Dr Julia Sevi and her team have long observed clinically – that skin regeneration is an ongoing process, not a single event.
Why Maintenance Treatments Are Essential
Regeneration Is Ongoing, Not One-Off
The skin’s regenerative cycle never stops, but like any physiological process, it slows over time. Collagen synthesis, elastin integrity, and cellular turnover all diminish with age and oxidative stress.
Polynucleotides counteract that decline, but their benefits need reinforcement. Without regular top-ups, fibroblast activity naturally falls back to baseline. Maintenance sessions, usually two to three times per year, re-energise the skin’s regenerative rhythm and preserve the results achieved during the induction phase.
Dr Julia Sevi often likens this to fitness: “You wouldn’t go to the gym for three months and expect lifelong strength. Skin health works the same way – it thrives on consistent stimulation.”
The Aesthetic Health Protocol
Under Dr Julia Sevi’s guidance, Aesthetic Health follows a structured, evidence-based approach to achieve sustainable, natural rejuvenation:
- Induction Phase – Three sessions, four weeks apart, to prime fibroblasts and trigger extracellular matrix renewal.
- Preservation Phase – Two to three sessions annually to maintain regeneration and hydration.
- Integration Phase – Polynucleotides are often combined with other modalities such as Ultherapy PRIME & Soundbite® Technique for collagen tightening or BioBlend® Regenerative Filler Solutions for structural restoration.
This multi-layered sequencing aligns with Aesthetic Health’s philosophy – results are built methodically, guided by anatomy, physiology, and the body’s natural healing intelligence.
The Clinical Outcomes You Can Expect
Patients who commit to both the initial course and maintenance sessions often describe results that feel progressive yet authentic. Clinical imagery and patient follow-ups reveal:
- Smoother, firmer skin texture
- Noticeably improved elasticity and hydration
- Calmer, more resilient skin tone
- Reduction in fine lines and uneven pigmentation
- Long-term dermal integrity with continuous care
These outcomes reflect biological rejuvenation, not surface enhancement – skin that simply looks rested, stronger, and healthier.
Safety and Tolerability
Polynucleotide injectables are well-tolerated when administered by qualified medical practitioners. Mild redness, puffiness, or tenderness may appear for 24-48 hours, but downtime is minimal.
Recent PMC 2024 safety reviews confirm an excellent safety record and no significant adverse events when used in medical-grade formulations. At Aesthetic Health, each treatment begins with a comprehensive medical assessment to ensure suitability and safety.
Meet the Experts
Dr Reem Koutaich and Dr Mobina Bohloli lead Aesthetic Health’s regenerative injectable programme. Both were personally trained by Dr Julia Sevi in advanced polynucleotide injection protocols, ensuring precision, safety, and scientifically grounded results.
Their approach is patient-centred, balancing artistry with medical accuracy to deliver subtle, confidence-building rejuvenation.
How to Preserve Your Results
For the best long-term outcome, schedule your preservation treatments throughout the year. This continuity keeps collagen activation at its peak and maintains hydration balance, allowing your skin to age gracefully and resiliently.
📍 Aesthetic Health – Leeds & London
🔗 Read our guide: What Are Polynucleotides? A Regenerative Breakthrough in Skin Health
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🔗 Doctor Mentorship Programme at Aesthetic Health
🔗 Meet Our Team
FAQ – Common Questions About Polynucleotides
- Are polynucleotides scientifically proven?
Yes. Numerous peer-reviewed studies demonstrate improvements in elasticity, hydration, and dermal repair, confirming their place as a clinically validated regenerative treatment.
- How long do polynucleotide results last?
Results build progressively and can last up to 12 months or longer when supported by regular maintenance sessions.
- How do polynucleotides differ from skin boosters or fillers?
Skin boosters hydrate temporarily; fillers restore volume. Polynucleotides stimulate repair, improving skin quality at a cellular level for natural-looking results.
- Can polynucleotides be combined with other treatments?
Absolutely. They work synergistically with Ultherapy PRIME, BioBlend®, microneedling, or laser therapies to enhance collagen formation and skin tone.
- Are maintenance treatments really necessary?
Yes, consistent stimulation keeps fibroblasts active, ensuring that collagen and elastin production remain stable over time. Without maintenance, these processes gradually decline.
Conclusion
In regenerative aesthetics, preservation is power. The clinical data on polynucleotides are clear: collagen renewal and extracellular matrix support require consistency. At Aesthetic Health, every treatment is prescribed, not promoted, as part of a scientifically grounded, personalised plan.
By combining cutting-edge evidence with Dr Julia Sevi’s diagnostic expertise, Aesthetic Health helps patients achieve not just rejuvenation, but true skin regeneration that endures beautifully through the years.
