What Are Polynucleotides? A Regenerative Breakthrough in Skin Health

Ageing is inevitable, but tissue decline doesn’t need to be.

Polynucleotides are fragments of DNA extracted from natural sources that work with your body to restore, regenerate, and repair the skin. They act as biostimulators, encouraging natural collagen synthesis, enhancing cellular renewal, and improving overall skin health from the inside out. Unlike conventional skin boosters or fillers, polynucleotides don’t just mask symptoms of ageing, they treat the underlying loss of structure and function.

These next-generation regenerative aesthetic treatments are changing the face of modern injectables. At Aesthetic Health, they are prescribed within a medically-led, diagnostic framework that prioritises long-term skin integrity, not short-term volume gain.

How Polynucleotide Injections Work at Every Layer of the Skin

Skin is complex, so treatments should be too. At Aesthetic Health, we don’t believe in surface-level solutions. Polynucleotides are injected at multiple depths to support tissue regeneration across key layers:

Injecting into the dermis vs subcutaneous layer

Dermal injections improve skin texture, hydration, and tone.
Subcutaneous injections support structure, boost elasticity, and promote volume resilience.

This multi-layer skin booster treatment addresses both visible concerns and underlying causes, from inflammation and dullness to laxity and collagen decline.

Why a Multi-Layered Approach Delivers Superior, Lasting Results

True rejuvenation is never one-dimensional.

Rather than simply injecting one substance into one area, our approach considers the biology of your skin and its individual regenerative capacity. Polynucleotides are meticulously placed to:

Reactivate dormant fibroblasts
Enhance blood flow and oxygenation
Increase hyaluronic acid production
Strengthen the skin barrier
Calm inflammatory responses

Over time, this leads to:

Smoother skin texture
Firmer contours
Fewer fine lines
Improved tone and hydration
Long-lasting results that evolve naturally over weeks

The result? Subtle, graceful rejuvenation, not a ‘done’ look.

Top Benefits of Polynucleotide Treatment for Ageing, Texture, and Inflammation

Polynucleotides go beyond cosmetic correction. They are biological repair agents that work in synergy with your skin’s own healing processes.

Benefits include:

Increased collagen and elastin production
Reduction in chronic skin inflammation
Improved skin density and hydration
Softening of fine lines and static wrinkles
Reversal of sun damage and environmental ageing
A brighter, more radiant complexion

They are particularly effective for treating:

Periorbital lines (under-eye hollows and crepiness)
Midface volume loss
Skin dehydration
Sensitivity or post-inflammatory pigmentation

Who Is Suitable for Polynucleotide Therapy?

Whether you are navigating the early signs of ageing or seeking long-term support for collagen stimulation, polynucleotides are suitable for a wide range of patients.

Ideal candidates include:

Individuals in their 30s to 70s looking for subtle, regenerative support
Patients with thin, crepey, or inflamed skin
Those wanting an alternative to traditional skin boosters or hyaluronic acid fillers
Clients in recovery from stress, sun damage, or skin procedures
Men and women who value natural-looking results rooted in science

This treatment is particularly well-suited for those who are new to injectables but desire a healthier, more resilient skin foundation.

What to Expect During and After Treatment

Your journey begins with a consultation at Aesthetic Health, where our practitioners assess your skin structure, underlying function, and long-term needs. Your plan will be tailored to include:

Number of sessions (usually 3-4 spaced over 4-6 weeks)
Target areas (e.g., periorbital, midface, neck, hands)
Product combinations (e.g., with PRP or CaHA for added stimulation)

What does the treatment feel like?

Small, superficial injections
Minimal discomfort
No general anaesthetic required

Downtime?

Mild redness or puffiness lasting 12-48 hours
Makeup can usually be worn the next day
Gradual results appearing over 2-6 weeks

Unlike aggressive treatments, polynucleotides respect your skin’s rhythm, healing, not shocking the system.

Why Polynucleotides Are Replacing Skin Boosters and Fillers

Patients today want more than quick fixes. They want solutions with integrity.

Polynucleotides are quickly becoming the preferred option over traditional skin boosters and dermal fillers because:

They don’t simply “fill”, they regenerate
They are safe, biocompatible, and well-tolerated
They improve long-term skin quality, not just short-term volume
They integrate seamlessly into personalised regenerative treatment plans

At Aesthetic Health, we use polynucleotides in tandem with other regenerative injectables, such as Radiesse (CaHA) and PRP, to create multi-dimensional, layered outcomes.

Book a Polynucleotide Consultation with Our New Specialists

Whether you are curious about non-surgical rejuvenation or ready to commit to a personalised regenerative treatment, our doctors offer expert guidance, outstanding care, and an integrative approach to skin health.

📍 Based in Leeds, our clinic holds an Outstanding CQC rating and a longstanding reputation for excellence.

Secure your consultation today and begin your journey toward stronger, healthier skin:
Book Your Appointment

FAQ – Top 5 Most Asked Questions (SEO Friendly)

1. What do polynucleotides do for the skin?

They stimulate collagen production, reduce inflammation, promote healing, and improve hydration, helping skin function better at every level.

2. How do polynucleotide injections work?

They are injected into the dermis and subcutaneous layers, where they reactivate fibroblasts, improve tissue oxygenation, and enhance skin regeneration over time.